Ethyl pyruvate modulates delayed paralysis following thoracic aortic ischemia reperfusion in mice
نویسندگان
چکیده
منابع مشابه
Ethyl Pyruvate Has Anti-Inflammatory and Delayed Myocardial Protective Effects after Regional Ischemia/Reperfusion Injury
PURPOSE Ethyl pyruvate has anti-inflammatory properties and protects organs from ischemia/reperfusion (I/R)-induced tissue injury. The aim of this study was to determine whether ethyl pyruvate decreases the inflammatory response after regional I/R injury and whether ethyl pyruvate protects against delayed regional I/R injury in an in vivo rat heart model after a 24 hours reperfusion. MATERIAL...
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Administration of pyruvate, an effective scavenger of reactive oxygen species, has been shown to be salutary in numerous models of redox-mediated tissue or organ injury. Pyruvate, however, is unstable in solution and, hence, is not attractive for development as a therapeutic agent. Herein, ethyl pyruvate, which is thought to be more stable than the parent compound, was formulated in a calcium-c...
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ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 2016
ISSN: 0741-5214
DOI: 10.1016/j.jvs.2015.06.214